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HomeVol 30,2020Vol 30,2020 No.6Details

Research progress on reversing tumor resistance based on the epigenetics of drug metabolizing enzymes and transporters

Update:Dec. 05, 2020Total Views:396Total Downloads:193 DownloadMobile

Author: Xiao-Li ZHENG 1, 2 Jia-Qi WANG 2, 3 Lu-Shan YU 2, 3 Su ZENG 2, 3

Affiliation: 1. National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, Guangdong Province, China 2. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang University, Hangzhou 310058, China 3. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Hangzhou 310058, China

Keywords: Tumor Drug resistance Drug metabolizing enzymes Drug transporter Epigenetics

DOI：10.12173/j.issn.1004-5511.2020.06.06

Reference:Zheng XL, Wang JQ, Yu LS, Zeng S. Research progress on reversing tumor resistance based on the epigenetics of drug metabolizing enzymes and transporters[J]. Yixue Xinzhi Zazhi, 2020, 30(6): 457-463. DOI: 10.12173/j.issn.1004-5511.2020.06.06.[Article in Chinese]

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Abstract

The molecular mechanisms related to drug metabolism of tumor resistance include drug inactivation, increase of drug efflux, and decrease of drug uptake, The epigenetic regulation mechanism of drug metabolizing enzymes and drug transporters, such as DNA Methylation, histone modification and non-coding RNA may design therapies aimed at preventing or reversing drug resistance. This paper reviews epigenetic changes of drug-metabolizing enzymes and drug transporters to overcome tumor multidrug resistance.

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