Progress of research into the role of autophagy related signal transduction pathways in bone metabolism

Update:Jul. 23, 2021Total Views:841Total Downloads:510 DownloadMobile

Author: Zhi-Zhuo LI 1 Li-Jun SHI 2 Fu-Qiang GAO 3 Wei SUN 3

Affiliation: 1. Department of Orthopedics, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China 2. Department of Orthopedics, Peking Union Medical College, China-Japan Friendship institute of Clinical Medicine, Beijing 100029, China 3. Beijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Beijing 100029, China

Keywords: Autophagy Bone Metabolism Signal Transduction Pathway Osteoblast Osteoclast

DOI:10.12173/j.issn.1004-5511.202011032

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Abstract

Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation. The main cells involved in bone metabolism include osteoblasts and osteoclasts, which play an important role in bone develop-ment and maintenance. It has been found that the level of autophagy is regulated by Sirtuin1 (SIRT1) and mitogen-activated protein kinase 8 (MAPK8)/Forkhead box O3 (FOXO3) in osteoblasts. In osteo-clasts, the level of autophagy is regulated mainly by Bcl-2 interacting coiled-coil protein 1 (Beclin-1), p62/sequestosome 1 (p62/SQSTM1), mammalian target of Rapamycin (mTOR) and hypoxia-inducible factor-1α (HIF-1α). The main focus of this article is a discussion of the autophagy related signal trans-duction pathways in bone metabolism and an analysis of the regulation of autophagy in osteoblasts and osteoclasts.

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References

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