Objectives  To evaluate the status of conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2018, and compare with the relevant content guidelines published in 2017. In order to find the changes in guidelines development and also provide implications for guidelines in China. 

Methods  The CNKI, WanFang Data and CBM were searched to collect clinical practice guidelines published in China in 2018 from January 1st to December 31st. Two researchers independently selected literature, extracted relevant information such as statements of conflict of interest and economic evidences; then, the analysis was performed by using the Microsoft Excel 2019 software. 

Results  A total of 92 clinical practice guidelines were included, in which 23 (25.00%) disclosed conflict of interest, 25 (27.17%) stated sources of funding, and 22 (23.91%) reported economic evidence, and half of the reported guidelines were supported by the National Key Research and Development Plan or Science and Technology Major Project of China (50.00%). However, of the 53 clinical practice guide released in 2017, 26.42% disclosed conflict of interest, 18.87% stated sources of funding, and 11.32% referred to economic evidence. 

Conclusion  Comparative analysis of conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2017-2018, with the increase of financial investment in the development of clinical practice guidelines in China, the attention to economic evidence has also increased, while, we found that the disclosed conflict of interest in the guidelines and the exact economic evidence are still very low. Therefore, we should further promote the report of conflict of interest statement and the generation of economic evidence in our clinical practice guidelines, which will make our guidelines more objective, transparent and independent.

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